检测认证人脉交流通讯录
供biovendor Uromodulin Human ELISA 欣博盛供
货号：RD191163200R
名称：Uromodulin Human ELISA
规格：96 wells (1 kit)
产品描述：
尿调节蛋白（tamm-horsfall蛋白，umod）是一种大约85kDa的糖蛋白，产生于肾小管亨勒环的厚上肢和肾小管的早期远曲小管。它是一种跨膜蛋白，通过糖基磷酰肌醇（GPI）锚的蛋白水解酶分解分泌到尿液中。它属于GPI家族。健康的人每天排泄数十毫克的尿调节蛋白，在尿液中形成最丰富的蛋白质。尿调节蛋白通过与细胞因子相互作用调节细胞粘附和信号转导，并抑制钙晶体的聚集。通过减少草酸钙沉淀，尿调节蛋白在肾结石形成方面起到保护作用，最近对易患肾结石的THP缺乏小鼠的研究表明。THP是一种宿主防御因子，可抵抗由大肠埃希菌、沙门葡萄球菌、奇异变形杆菌和肺炎克雷伯氏菌等泌尿病原体引起的尿路infect。尿调节蛋白与大肠杆菌1型菌毛结合，从而阻断尿路上皮细胞的定植。tamm-horsfall蛋白与其他分子和细胞相互作用，包括IL-1、IL-2、TNF、IGG、中性粒细胞、淋巴细胞和单核细胞。尿调节蛋白与中性粒细胞的结合诱导IL-8的合成，刺激呼吸爆发和脱粒，刺激趋化和吞噬。最近，全基因组关联研究发现尿调节蛋白是慢性肾病和hypertensi的危险因素。尿调节蛋白基因突变与三种常染色体显性肾小管间质性肾病有关，如家族性青少年高尿酸血症性肾病（FJhn）、髓质囊性肾病（Mckd2）和肾小球系统性肾病（GCKd）。这些疾病的特点是青少年开始高尿酸血症，痛风和进行性肾衰竭。
特点：
European Union: for in vitro diagnostic use
Rest of the world: for research use only!
The total assay time is less than 3.5 hours
The kit measures uromodulin in serum, plasma (EDTA, citrate, heparin) and urine
Assay format is 96 wells
Standard is native protein based
Quality Controls are human serum based
Components of the kit are provided ready to use, concentrated or lyophilized
类型：Sandwich ELISA, Biotin-labelled antibody
别名：Tamm-Horsfall urinary glycoprotein, THP, UMOD
物种：Human
样本浓度：10 µl/well
校准范围：0.5–32 ng/ml
检测限：0.12 ng/ml
应用：Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate, Urine
运输：At ambient temperature. Upon receipt, store the product at the temperature recommended below
储存/到期：tore the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
交叉反应：
bovine Non-detectable
cat Non-detectable
dog Non-detectable
goat Non-detectable
hamster Non-detectable
horse Non-detectable
human Yes
pig Non-detectable
rabbit Non-detectable
rat Non-detectable
sheep Non-detectable
chicken Not tested
monkey Yes
mouse Non-detectable
试剂盒组成：
Antibody Coated Microtiter Strips 96 wells
Biotin Labelled Antibody Conc. (10x) 1.3 ml
Streptavidin-HRP Conjugate 13 ml
Master Standard 2 vials
Quality Control HIGH 2 vials
Quality Control LOW 2 vials
Dilution Buffer 20 ml
Biotin-Ab Diluent 13ml
Wash Solution Conc.(10x) 100 ml
Substrate Solution 13 ml
Stop Solution 13 ml
Product Data Sheet + Certificate of Analysis 1 pc
Biovendor是欧洲的一家生物医药科技公司,其科研及诊断产品事业部成立于1995年。Biovendor公司专注于研发与生产诊断及科研用途的免疫检测试剂盒、抗体以及重组蛋白等产品。
产品覆盖以下研究领域, 主要提供ELISA试剂盒，重组蛋白及相关抗体
凋亡(Apoptosis)
糖尿病-胰岛素、C-肽、胰岛素原
(Diabetology - Insulin, C-Peptide, Proinsulin)
肌生长调控
(Muscle Growth Control)
自身免疫 (Autoimmunity)
糖尿病-其他相关产品
(Diabetology - Other Relevant Products)
神经组织标志物
(Neural Tissue Markers)
血压调节和NO代谢
(Blood Pressure Regulation And NO Metabolism)
能量代谢和体重调节
(Energy Metabolism And Body Weight Regulation)
肿瘤学 (Oncology)
骨与软骨代谢
(Bone And Cartilage Metabolism)
生长hormone和生长因子相关
(Growth Hormone And Factor-related Products)
氧化应激 (Oxidative Stress)
心血管疾病
(Cardiovascular Disease)
免疫应答、infect和炎症反应
(Immune Response, Infection And Inflammation)
胰调控分子
(Pancreatic Regulatory Molecules)
细胞粘连蛋白 (Cell Adhesion Proteins)
免疫学 (Immunology)
肾脏疾病 (Renal Disease)
细胞因子、趋化因子及相关分子
(Cytokines And Chemokines And Related Molecules)
铁代谢(Iron Metabolism)
生殖 (Reproduction)
糖尿病-自身免疫
(Diabetology – Autoimmunity)
脂蛋白代谢
(Lipoprotein Metabolism)
细胞表面蛋白
(Cell Surface Proteins (sCD) )
分泌型磷脂酶A2
(Secreted Phospholipases A2 show all)
血清学 (Serology)
类固醇hormone
(Steroid Hormones)
移植 (Transplantation)
动物相关研究 (Animal Studies)
其他研究领域 (Others)
产品编号
产品名称
规格
检测限
标曲范围
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